In addition to our commitment to offering the most up-to-date care available for children with diabetes, our providers are also continually conducting research in the field of diabetes. Our faculty study a wide range of topics, including health outcomes and quality of life for children with diabetes, and the link between childhood obesity and its long-term endocrine consequences such as pubertal maturation.
U-M faculty also explore ways to improve the tools available to families to support them in managing their child’s diabetes. We focus on providing patients information about the latest diabetes technology (such as insulin brands, pumps, continuous glucose monitors) to allow them to decide if it right for them. See below for additional information about some of our current studies.
If you would like to search for eligible research studies not listed below, click here.
Actively Recruiting Studies
Adolescent Interventions to Manage Self-Regulation of T1D (AIMS T1D)
Are you the parent of a teen with type 1 diabetes who is concerned about how your child manages the condition? We are looking to see if teaching teens new skills in relaxation and thinking about the future improves how they manage their T1D.
There will be 2 study visits for all parents and teens and 2 blood draws for teens. The first visit lasts about 2 hours, the second one about 1.5 hours. There is also some home practice on computer tablets for about half the teens that will take another hour or two per week. The whole study lasts about 8 weeks or 2 months. The study visits will take place in Ann Arbor at the 300 North Ingalls Building, where we offer free reserved parking.
We are recruiting for this study! Families will be compensated up to $275 on MasterCard gift cards for completing the visits (up to $175 for teens and up to $100 for parents). The teens who complete their home practice activities could earn more and be entered into a lottery for a gift card.
We are looking for teens and parent/guardians who meet the following:
Teen is between 13-17 years of age
Teen has Type 1 Diabetes (diagnosed at least 6 months) with HbA1c ≥ 7.0
Teen is a patient of C.S. Mott Children’s Hospital Pediatric Endocrinology
Parent/guardian and teen live in the same household
Parent/guardian and teen have access to a smartphone and Wi-Fi
Parent/guardian and teen are fluent in English
The principal investigators of this study are Dr. Alison Miller, School of Public Health, and Dr. Emily Fredericks, Department of Pediatrics. If you would like to participate and/or have any questions, please contact the AIMS Study team at AIMS.T1D.Study@umich.edu or (734) 764-9133.
Visit UMHealthResearch.org to learn more about this study!
AIMS Parents Study
Are you the parent of an 11-17 year old with Type 1 Diabetes? The purpose of this study is to understand how factors like parents’ stress and emotions may influence their children’s diabetes management. This study consists of 1 visit at our U-M offices, your home, or a community private space. You may also be able to participate in the hybrid study visit model where activities are completed partly online and partly in-person. The total study visit time is approximately 1.5 hours.
Parents of 11 to 17 year olds who have had T1D for at least 6 months are invited to participate. Parents must live in the same household as their children and be able to complete study activities in English. We will also collect information from children’s medical records and link that information to information collected from parents as part of the study.
Parents will be compensated $50 on a gift card for participating in this study.
If you would like to participate and/or have any questions, please contact the AIMST1D Parents study research team at AIMS.Parents.Study@umich.edu or (734) 764-9133.
Visit UMHealthResearch.org/#studies/HUM00158023 to learn more about the study!
Type 1 Diabetes eHealth Study
The purpose of this 6-month study is to understand how an eHealth model can be used in diabetes care, and will help create technology that can promote collaboration between patients, caregivers, and their healthcare providers.
Up to 25 children or young adults with type 1 diabetes who receive their care from providers at C.S. Mott Children’s Hospital Pediatric Endocrinology and at least one adult parent/guardian (if under 18) will participate in a total of 3 virtual interviews, 2 telemedicine video visits and 10 virtual data review sessions with either an endocrinologist or diabetes educator from the U-M Pediatric Diabetes Team. These visits will be conducted using secure software on a laptop or mobile device. Before each of these visits, participants will upload their diabetes data to an online platform, and after each of these visits, a brief survey will be completed. Interviews will be conducted at the beginning, middle, and end of the 6-month study period.
Each patient and parent/guardian pair or young adult will receive up to a $225.00 gift card in compensation for completing the entire 6-month study.
Participation in this study is voluntary. We will enroll up to 25 child and parent/guardian pairs or young adults who meet all of the following:
Child or young adult with clinical diagnosis of type 1 diabetes who is less than age 25 and is a patient of C.S. Mott Children’s Hospital Pediatric Endocrinology*
Parent/guardian and child have access to internet
Parent/guardian and child have access to a laptop or mobile device with webcam capabilities
Parent/guardian is willing to participate in telemedicine for their child’s diabetes and is willing to sign the Michigan Medicine telemedicine consent
Parent/guardian is willing to download and send diabetes data remotely every 2 weeks via Tidepool or another diabetes data platform
Parent/guardian is willing to have the child complete blood work (HbA1c) at a local laboratory/testing facility prior to study telemedicine video visits
*This study is limited to patients of the study investigator, Dr. Joyce Lee. You or your participating health plan will pay for the telemedicine visits. Please contact the study team to verify if you are eligible to participate.
If you have any questions, please contact the Study Coordinator, Valerie Gavrila at firstname.lastname@example.org or (734) 936-6042.
Type 1 Diabetes TrialNet Pathway to Prevention Study
What is TrialNet?
TrialNet is a network of 18 clinical centers working with more than 200 screening sites throughout the United States, Canada, Finland, United Kingdom, Italy, Australia, and New Zealand. This network is dedicated to the study, prevention, and early treatment of type 1 diabetes.
What is the Pathway to Prevention Study?
The Type 1 Diabetes TrialNet Pathway to Prevention Study screens relatives of people with type 1 diabetes. Relatives of people with T1D have about 15 times greater risk for developing the disease than people with no family history. This unique screening can identify the early stages of T1D years before any symptoms appear. It also helps researchers learn more about how T1D develops and plan new studies exploring ways to prevent it.
You can be screened as part of the study if you are:
1 to 45 years old and have a brother, sister, child, or parent with T1D
1 to 20 years old and have a cousin, aunt, uncle, niece, nephew, half-brother, half-sister, or grandparent with T1D
Have not been diagnosed with diabetes
How is the test done?
A small sample of blood is drawn from your arm. The blood is tested for autoantibodies. Autoantibodies are markers that show that the immune system is turned on. You can have the blood drawn at a TrialNet site or we can send you a test kit that you take to your doctor or local lab to have your blood drawn, and then you send it to us. We will have the results in 4 to 6 weeks.
Ongoing Research Studies
T1D Exchange Clinic Network & Registry
The T1D Exchange Clinic Registry is coming to an end! Thank you for your participation!
By taking part in the T1D Exchange Clinic Registry, you have supported improvements such as:
Blood glucose meter strip coverage by insurers
A change in the American Diabetes Association guidelines for HbA1c goals for pediatric patients
The FDA decision to expand the Dexcom Continuous Glucose Monitor labeling to include fingerstick replacement
Continuous Glucose Monitor coverage by Medicare
You can continue to make an impact!
The Clinic Registry accelerated care solutions and influenced policy and insurance coverage. Now the Virtual Registry will continue that important work. Join the Virtual Registry and lend us your voice! You will receive a $20 gift card for completing the first survey.
The Effects of Diet-Induced Obesity on Hematopoiesis
In order to understand the source of inflammation we have focused on understanding changes within the hematopoietic compartment. The prominent white blood cell increased and activated during obesity is the macrophage. We have focused our studies on looking at the generation of myeloid cells (macrophages and neutrophils) and how this is enhanced in the bone marrow of obese mice. These changes are sustained even after bone marrow transplantation and weight loss. By investigating the changes within these progenitors we will gain knowledge and understanding of the long-term persistent impact of diet-induced obesity on the immune system.
For more information, check the Singer Lab research website.