Research

In addition to our commitment to offering the most up-to-date care available for children with diabetes, our providers are also continually conducting research in the field of diabetes. Our faculty study a wide range of topics, including health outcomes and quality of life for children with diabetes, and the link between childhood obesity and its long-term endocrine consequences such as pubertal maturation.

 

U-M faculty also explore ways to improve the tools available to families to support them in managing their child’s diabetes. We focus on providing patients information about the latest diabetes technology (such as insulin brands, pumps, continuous glucose monitors) to allow them to decide if it right for them. See below for additional information about some of our current studies.

If you would like to search for eligible research studies not listed below, click here.

Actively Recruiting Studies

Promoting Collaborative Health Management for Pediatric Patients with T1D

We are conducting a research study to better understand how type 1 diabetes is managed and how children are engaged in their diabetes care. 

 

Who is eligible to participate in this study? (Must meet all criteria)

  • Age (years) is between 6 and 12  

  • Child is diagnosed with type 1 diabetes (T1D) and uses a Dexcom Continuous Glucose Monitor

  • Both child and one parent/legal guardian are willing to take part in the research interview

  • English speaking

What will happen to me in this study?

If you decide to participate, child and parent/guardian will take part in three sessions: 1) pre-interview session (1 hour), 2) data collection session where child and parent/guardian will freely log data using an electronic or paper diary at least once daily as well as share child's Dexcom CGM data with the study team (up to 3 weeks), and 3) post interview session (1 hour). The interview will be recorded.

We may ask you some questions about:

  • Experience of tracking health-related data (e.g. meals, activities that can impact blood sugar)

  • How health-related information is tracked, interpreted, and shared by parent and child

  • The roles of child and parent(s) for tracking data

  • Daily challenges and lessons learned from tracking data

If you would like to participate and/or have any questions, please contact Yoon Cha (yjcha@umich.edu).

For more details, please visit: https://umhealthresearch.org/#studies/HUM00214908

Type 1 Diabetes TrialNet Pathway to Prevention Study

Did you know that relatives of people with type 1 diabetes have 15 times greater risk for developing the disease than people with no family history?

 

We are partnering with the University of Michigan TrialNet team to prevent type 1 diabetes and we encourage you to get involved. TrialNet is an international network of researchers seeking ways to delay or prevent type 1 diabetes. TrialNet offers risk screening to relatives of people with type 1 diabetes to see if they are at risk for developing the disease. The screening is a free blood test that can detect the risk for type 1 diabetes years before symptoms appear. Most of this process can be completed from home!

 

How can you get involved?

 

If someone in your family has type 1 diabetes, you can sign up at UMHSTrialNet@med.umich.edu to have a test kit mailed to you, free of charge, to obtain a screening sample. You can order an in-home test kit, or a lab test kit that you take to a lab for the blood draw. Test kits can be mailed to you anywhere in the US and all of the paperwork can be completed electronically. If testing shows that you are at increased risk for type 1 diabetes, you can be monitored by TrialNet and may be eligible to join a research study testing ways to prevent or delay the disease.

 

Who is eligible to be screened?

  • Anyone ages 2.5 through 45 with a sibling, child, or parent with type 1 diabetes.

  • Anyone ages of 2.5 through 20 with a sibling, child, parent, cousin, aunt, uncle, niece, nephew, grandparent or half-sibling with type 1 diabetes.

 

For more information, please call (734) 615-4079 or email Sheree Nicholson, Clinical Subject Coordinator at UMHS-TrialNet@med.umich.edu. We hope to hear from you soon!

Ongoing Research Studies

The Effects of Diet-Induced Obesity on Hematopoiesis

In order to understand the source of inflammation we have focused on understanding changes within the hematopoietic compartment. The prominent white blood cell increased and activated during obesity is the macrophage. We have focused our studies on looking at the generation of myeloid cells (macrophages and neutrophils) and how this is enhanced in the bone marrow of obese mice. These changes are sustained even after bone marrow transplantation and weight loss. By investigating the changes within these progenitors we will gain knowledge and understanding of the long-term persistent impact of diet-induced obesity on the immune system.

For more information, check the Singer Lab research website.