Research

In addition to our commitment to offering the most up-to-date care available for children with diabetes, our providers are also continually conducting research in the field of diabetes. Our faculty study a wide range of topics, including health outcomes and quality of life for children with diabetes, and the link between childhood obesity and its long-term endocrine consequences such as pubertal maturation.

 

U-M faculty also explore ways to improve the tools available to families to support them in managing their child’s diabetes. We focus on providing patients information about the latest diabetes technology (such as insulin brands, pumps, continuous glucose monitors) to allow them to decide if it right for them. See below for additional information about some of our current studies.

If you would like to search for eligible research studies not listed below, click here.

Actively Recruiting Studies

Adolescent Interventions to Manage Self-Regulation of T1D (AIMS T1D)

Are you the parent of a teen with type 1 diabetes who is concerned about how your child manages the condition? We are looking to see if teaching teens new skills in relaxation and thinking about the future improves how they manage their T1D.

There will be 2 study visits for all parents and teens and 2 blood draws for teens. The first visit lasts about 2 hours, the second one about 1.5 hours. There is also some home practice on computer tablets for about half the teens that will take another hour or two per week. The whole study lasts about 8 weeks or 2 months.

 

The study visits will take place in Ann Arbor at the 300 North Ingalls Building, where we offer free reserved parking. 

 

We are recruiting for this study! Families will be compensated up to $275 on MasterCard gift cards for completing the visits (up to $175 for teens and up to $100 for parents). The teens who complete their home practice activities could earn more and be entered into a lottery for a gift card.

We are looking for teens and parent/guardians who meet the following:

  • Teen is between 13-17 years of age

  • Teen has type 1 diabetes (diagnosed at least 6 months) with HbA1c ≥ 7.0

  • Parent/guardian and teen live in the same household

  • Parent/guardian and teen have access to a smartphone and Wi-Fi

  • Parent/guardian and teen are fluent in English

The principal investigators of this study are Dr. Alison Miller, School of Public Health, and Dr. Emily Fredericks, Department of Pediatrics. If you would like to participate and/or have any questions, please contact the AIMS Study team at AIMS.T1D.Study@umich.edu or (734) 764-9133.

Visit UMHealthResearch.org to learn more about this study!

AIMS T1D Parents Study

Are you the parent of an 10-17 year old with Type 1 Diabetes? The purpose of this study is to understand how factors like parents’ stress and emotions may influence their children’s diabetes management. This study consists of 1 visit at our U-M offices, your home, or a community private space. You may also be able to participate in the hybrid study visit model where activities are completed partly online and partly in-person. The total study visit time is approximately 1.5 hours.

Parents of 10 to 17 year olds who have had T1D for at least 6 months are invited to participate. Parents must live in the same household as their children and be able to complete study activities in English. We will also collect information from children’s medical records and link that information to information collected from parents as part of the study.

Parents will be compensated $50 on a gift card for participating in this study.

If you would like to participate and/or have any questions, please contact the AIMS T1D Parents study research team at AIMS.Parents.Study@umich.edu or (734) 764-9133.

Visit UMHealthResearch.org/#studies/HUM00158023 to learn more about the study!

Type 1 Diabetes TrialNet Pathway to Prevention Study

Did you know that relatives of people with type 1 diabetes have 15 times greater risk for developing the disease than people with no family history?

 

We are partnering with the University of Michigan TrialNet team to prevent type 1 diabetes and we encourage you to get involved. TrialNet is an international network of researchers seeking ways to delay or prevent type 1 diabetes. TrialNet offers risk screening to relatives of people with type 1 diabetes to see if they are at risk for developing the disease. The screening is a free blood test that can detect the risk for type 1 diabetes years before symptoms appear. Most of this process can be completed from home!

 

How can you get involved?

 

If someone in your family has type 1 diabetes, you can sign up at UMHSTrialNet@med.umich.edu to have a test kit mailed to you, free of charge, to obtain a screening sample. You can order an in-home test kit, or a lab test kit that you take to a lab for the blood draw. Test kits can be mailed to you anywhere in the US and all of the paperwork can be completed electronically. If testing shows that you are at increased risk for type 1 diabetes, you can be monitored by TrialNet and may be eligible to join a research study testing ways to prevent or delay the disease.

 

Who is eligible to be screened?

  • Anyone ages 2.5 through 45 with a sibling, child, or parent with type 1 diabetes.

  • Anyone ages of 2.5 through 20 with a sibling, child, parent, cousin, aunt, uncle, niece, nephew, grandparent or half-sibling with type 1 diabetes.

 

For more information, please call (734) 615-4079 or email Andrea Haddad, MS, CCRP at UMHS-TrialNet@med.umich.edu. We hope to hear from you soon!

Ongoing Research Studies

The Effects of Diet-Induced Obesity on Hematopoiesis

In order to understand the source of inflammation we have focused on understanding changes within the hematopoietic compartment. The prominent white blood cell increased and activated during obesity is the macrophage. We have focused our studies on looking at the generation of myeloid cells (macrophages and neutrophils) and how this is enhanced in the bone marrow of obese mice. These changes are sustained even after bone marrow transplantation and weight loss. By investigating the changes within these progenitors we will gain knowledge and understanding of the long-term persistent impact of diet-induced obesity on the immune system.

For more information, check the Singer Lab research website.

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